Gene Therapy in Lung Disease (Lung Biology in Health and Disease) by Steven M. Albeda

Cover of: Gene Therapy in Lung Disease (Lung Biology in Health and Disease) | Steven M. Albeda

Published by Informa Healthcare .

Written in English

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  • Medical Genetics,
  • Respiratory medicine,
  • Respiratory Diseases,
  • Medical,
  • Medical / Nursing,
  • Genetics,
  • Pulmonary & Thoracic Medicine,
  • Medical / Pulmonary & Thoracic Medicine,
  • Life Sciences - Genetics & Genomics,
  • Diseases,
  • Gene therapy,
  • Lung Diseases,
  • Lungs,
  • Treatment,
  • therapy

Book details

The Physical Object
Number of Pages576
ID Numbers
Open LibraryOL11431608M
ISBN 100824708202
ISBN 109780824708207

Download Gene Therapy in Lung Disease (Lung Biology in Health and Disease)

Containing over references, Gene Therapy in Lung Disease is designed for pulmonologists and pulmonary disease specialists, geneticists, physiologists, biochemists, molecular and cell biologists, pediatricians, pathologists, pharmaceutical industry scientists, primary care physicians, and graduate-level and medical school students in these : Hardcover.

Gene Therapy for Diseases of the Lung (Lung Biology in Health and Disease): Medicine & Health Science Books @ Skip to main content Try PrimeAuthor: Kenneth Brigham.

Gene Therapy for Diseases of the Lung - CRC Press Book This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for Gene Therapy in Lung Disease book further development of safe and efficient gene delivery systems.

Book Review: Gene Therapy in Lung Disease. StevenM Albelda, editor. (Lung Biology in Health and Disease series, VolumeClaude Lenfant, executive editor).Author: Arlene Stecenko. The lung is a major target of gene therapy for genetic disorders, such as cystic fibrosis and alpha1-antitrypsin deficiency, and for other diseases, including lung cancer, malignant mesothelioma, pulmonary inflammation, surfactant deficiency, and pulmonary hypertension.

In the case of gene therapy in the lung, the airway epithelia or even the lung vasculature may be efficient cellular targets.

The route of administration has to be defined so as the target gene is transported to the target cells in order to perform the transfection of the target tissue by: 1. Prophylactic gene therapies administered to the lungs of CF ferrets prior to cessation of VX can be used to test whether the gene therapy approach prevents the development of lung disease.

This approach circumvents a potential barrier (thick mucus) in the CF airway that may impede gene transfer to the airways and addresses whether the gene Cited by: 2. Acquired lung diseases may also be candidates for gene therapy.

Forinstance, primary pulmonary hypertension may be amenable to genetherapy, even though Lung cancer isanother likely candidate for gene therapy.x7Gene therapy for lung by: Non-respiratory lung functions are mechanical, biochemical, and physiological.

The lungs provide a defense against bacterial, viral and other infectious agents; remove various metabolic waste products; control the flow of water, ions, and large proteins across its cellular structures; and manufacture a variety of essential hormones and chemical agents that have important biological roles.

“In the future it may be possible to cure CF by either adding normal cystic fibrosis genes to lung cells using gene therapy, or by repairing the defective cystic fibrosis gene using gene editing.

Unlocks the biological mysteries of infection, immunity, cytokine behavior, and fibrosis, and illustrates the use of gene therapy to treat lung cancer, pulmonary vascular diseases, a1-antitrypsin This work is designed for pulmonologists and pulmonary disease specialists, and others.

Book Description. This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery.

Gene Gene Therapy in Lung Disease book in Lung Disease. DOI link for Gene Therapy in Lung Disease. Gene Therapy in Lung Disease bookCited by: 6. Therefore, the use of genomic constructs which contain the introns and flanking DNA of the therapeutic gene is expected to be more effective than that of mini-gene/cDNA constructs in gene therapy for certain genetic diseases where precise levels of the gene product are required.

There is evidence that CF is such a : George Kotzamanis, Athanassios Kotsinas, Apostolos Papalois, Vassilis G. Gorgoulis. Get this from a library.

Gene therapy in lung disease. [Steven M Albelda;] -- This publication highlights regulatory issues and advances in the design and application of liposomes and replicating adenoviral and adeno-associated viral vectors for the study and treatment of.

The book offers an insight into repair mechanisms of the diseased lung, the role of specific lung niches and provides information on initial clinical trials as well as the use of stem cells as vehicles for gene therapy. Gene Therapy for Diseases of the Lung by Kenneth L.

Brigham,available at Book Depository with free delivery worldwide. Abstract. Gene therapy is under development for a variety of lung disease, both those caused by single gene defects, such as cystic fibrosis and α 1-antitrypsin deficiency, and multifactorial diseases such as cancer, asthma, lung fibrosis, and viral and nonviral approaches have been explored, the major limitation to the former being the inability to repeatedly administer, which Author: Eric W.F.W.

Alton, Jane C. Davies, Duncan M. Geddes. Gene therapy for cystic fibrosis lung disease 49 reported that a drug such as PTC may not be effective in all cases of pre- mature stop codons, due to exonic skipping which removes the early stop.

“Chronic obstructive pulmonary disease (COPD) is regarded as a disease of accelerated lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening, cellular senescence, activation of PI3 kinase-mTOR signaling, impaired autophagy, mitochondrial dysfunction, stem cell exhaustion.

Recombinant Adenovirus. Adenovirus has been one of the most extensively studied recombinant viral systems for gene transfer to the lung (12). Adenovirus has a large, complex linear kb DNA genome and is attractive for gene therapy to the lung because it efficiently transduces non-dividing cells of Cited by:   Gene Therapy and Lung Disease Peter D.

Wagner. and Blood Institute (NHLBI), and Marcel Dekker began a series of books that would present up-to-date and comprehensive reviews of pulmonary science in health and disease.

To date, separate volumes have appeared, and the subject of this review is volume applications of gene transfer Author: Peter D. Wagner. Gene Therapy and Lung Disease Gene Therapy and Lung Disease Wagner, Peter D.

Journal of Heredity (3)– ª The American Genetic Association Book Reviews Gene Therapy and Lung Disease Chief, Division of Physiology Interim Director, Division of Pulmonary and Edited by Steven M. Albelda. Critical Care Medicine Marcel Dekker, New York. Gene therapy is a new field of medical research that has great potential to influence the course of treatment of human disease.

The lung has been a particularly attractive target organ for gene therapy due to its accessibility and the identification of genetic deficits for a number of lung by: Title: Gene Therapy for Lung Diseases Development in the Vector Biology and Novel Concepts for Gene Therapy Applications VOLUME: 1 ISSUE: 1 Author(s):M.

Suzuki, T. Matsuse and Y. Isigatsubo Affiliation:Dept. of Pulmonary Medicine, Yokohama University Medical Center, Kanagawa,Japan Keywords:Gene Therapy, cystic fibrosis, Acute lung injury, Inflammatory, Lung cancer, Cited by: Gene therapy employs the specific transfer of genetic materials to have an impact upon a disease process.

This form of therapy, therefore, requires a basic understanding of the molecular pathogenesis of the targeted diseases. 29 As research continues to provide new understanding about the molecular pathogenesis of lung cancer, gene therapy will Cited by: Gene Therapy for Cystic Fibrosis.

Cystic fibrosis is caused by mutations in the gene responsible for producing the cystic fibrosis transmembrane conductance regulator (CFTR) protein. For this reason, scientists are exploring ways to provide a correct copy of the gene to treat CF. Gene therapy for sickle cell disease: A patient’s story Septem During Sickle Cell Awareness Month, Alabamian Lynndrick Holmes, 29, shared his experience of being free of the sickle cell disease two years after receiving genetic treatment as part of an NIH clinical trial that might hold the key to a cure of this disease.

Abstract. The genetic basis of some nonneoplastic lung diseases and the accessibility of the pulmonary airways for administration of aerosol therapy make the concept of gene therapy for these diseases one worthy of the intense examination that it has been given.

1 Cystic fibrosis (CF) and α 1-antitrypsin deficiency (AATD), two common and incurable lung diseases that are caused by mutations in Author: Timothy Craig Allen, Philip T. Cagle, Philip T. Cagle. The development of lung cancer treatment have come a long way within the last decade.

The progression of gene therapy through clinical trials is contributing to millions of lives extended as well as more patients going into remission. The success gene therapy is playing towards these common cancers are making waves in the rare space as well.

gene therapy, the use of genes and the techniques of genetic engineering in the treatment of a genetic disorder or chronic disease. There are many techniques of gene therapy, all of them still in experimental stages.

The two basic methods are called in vivo and ex vivo gene therapy. After more than two decades since clinical trials tested the first use of recombinant adeno-associated virus (rAAV) to treat cystic fibrosis (CF) lung disease, gene therapy for this disorder has undergone a tremendous resurgence.

Centro Nacional de Investigaciones Oncológicas (CNIO). (, January 30). Lung fibrosis cured in mice with a gene therapy that lengthens telomeres.

ScienceDaily. In Augustscientists made a blockbuster discovery: They pinpointed the faulty gene that causes cystic fibrosis, a cruel lung disease that killed many of its victims before they reached. New targeted gene therapy could lead to improved treatment for emphysema Date: July 5, Source: Boston University Medical Center Summary: Researchers have developed a new strategy using lung.

It is estimated that there will be approximatelydeaths caused by lung cancer in This technology will help in improving the quality of life of lung cancer patients as well as other cancers.

Additionally, the gene therapy market is now a multi-million dollar industry. Need for Alternate Therapy Genetic lung diseases are fatal and they represent a significant health care burden.

Despite extensive understanding of the genetics, definitive treatment options are lacking. Because many genetic lung diseases are monogenic in nature, they are promising targets for treatment using gene-editing technologies.

Common lung diseases. adult respiratory distress syndrome (ARDS): Usually viral in origin, the acute shortness of breath is very similar to the RSD of premature babies atelectasis: A collapse of a segment of the lower lung, usually in the lower lung area ASTHMA: Asthma Introduction, Classification of Severity, Asthma Signs and Symptoms, Diagnostic Tests for Asthma, Asthma Treatment.

gene mutations cause disease and will focus largely on the respiratory tract. In addition, new therapeutic targets and compounds that have arisen from this improved under-standing will be discussed. Pathophysiology A brief and simplified cascade of the current concept of how lung disease evolves in CF is summarized in Figure 1.

Gene Therapy Begins For Fatal Lung Disease. By Natalie syringe used to administer the gene therapy into the man's lung. develop a treatment that gets to the cause of the disease. Gene therapy is designed to introduce genetic material into cells to compensate for or correct abnormal genes.

If a mutated gene causes damage to or spurs the disappearance of a necessary protein, for example, gene therapy may be able to introduce a normal copy of the gene .Cystic fibrosis (CF) is one of the most common fatal hereditary diseases.

The discovery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the stage for unraveling the pathogenesis of CF lung disease, continuous refinement of symptomatic treatments and the development of mutation-specific therapies, which are now becoming available for a subgroup of .Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy.

These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research.

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