DNA repair in cancer therapy molecular targets and clinical applications by Mark Richard Kelley

Cover of: DNA repair in cancer therapy | Mark Richard Kelley

Published by Elsevier/Academic Press in London, Waltham, MA .

Written in English

Read online

Subjects:

  • Genetics,
  • Cancer,
  • Neoplasms,
  • Genetic aspects,
  • DNA repair,
  • Treatment,
  • DNA Repair,
  • Drug therapy

Edition Notes

Includes bibliographical references and index.

Book details

Statementedited by Mark R. Kelley
Classifications
LC ClassificationsRC270.8 .D53 2012
The Physical Object
Paginationxiii, 316 p. :
Number of Pages316
ID Numbers
Open LibraryOL25141068M
ISBN 100123849993
ISBN 109780123849991
LC Control Number2011293621
OCLC/WorldCa711573687

Download DNA repair in cancer therapy

Publisher Summary. This chapter provides an overview of DNA repair targets. The critical role of DNA repair in preventing cancer in humans first came to light in studying individuals with xeroderma pigmentosum (XP), a rare recessive genetic disorder characterized by the inability to repair DNA damage caused by ultraviolet light.

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.

Experts on DNA repair proteins from all. DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.

Experts on DNA repair proteins from all areas of cancer biology research take readers from. Emerging clinical data provide compelling evidence that overexpression of DNA repair factors may have prognostic and predictive significance in patients. In this chapter, we will provide an overview of major DNA repair pathways and describe recent advances in anticancer therapy with a focus on DNA repair in cancer.

Oct 20,  · "DNA Repair in Cancer Therapy is an excellent primer for the cancer researcher interested in learning about the role of DNA repair in malignancy. Its chapters are accessible to the generalist yet offer a depth of discussion which is both comprehensive and 3rdrailphotography.com Edition: 1.

Interrupting DNA repair in such a way that shuts down a tumor's compensatory repair mechanisms and induces cell death is the goal of all research surrounding DNA repair inhibition. DNA repair inhibitors, particularly small-molecule inhibitors, hold great promise for damaging tumor 3rdrailphotography.com by: "Oncometabolites, DNA repair, and cancer therapy" Conference Summary.

Scientific Programme Committee. Lunch & Depart. Click here for a printable version of the programme. Export programme to PDF List of Participants If you attend, we will include your name and country in the printed programme book unless you request to be removed.

This book is absolutely the most comprehensive and well written book in this field. The pictures are astounding, and the layout is superb. The whole book is great but, the chapters written by G. Walker are particularly enlightening. Anyone with even a mild intrest in DNA Repair and or Mutagenesis should purchase this book with utmost 3rdrailphotography.com by: One of the most well-known examples of a defect in DNA repair leading to cancer is the association of germ-line BRCA1/2 mutations with breast, ovarian and peritoneal malignancies.

These rare human DNA repair syndromes have been invaluable in providing mechanistic explanations for the involvement of DNA repair system in 3rdrailphotography.com by: 4. Oct 22,  · In part, this reflects most cancer cells being DDR-impaired and them proliferating more rapidly than most normal cells (S phase is a particularly vulnerable time for DNA-damage exposure).

Nevertheless, DNA repair provides a common mechanism for cancer-therapy resistance. Consult your health care provider to discuss the possibility of tumor DNA sequencing as part of your care.

Tumor DNA sequencing is most common (and most beneficial) for patients with cancer types that may be susceptible to treatment with a targeted therapy. These patients are commonly tested for the genetic mutation the therapy targets.

Apr 23,  · Since the beginning of cancer therapy, genotoxic agents that trigger DNA damage checkpoints have been applied to halt the growth and trigger the apoptotic demise of cancer cells. We provide an overview about the involvement of DNA repair systems in cancer prevention and the classes of genotoxins that are commonly used for the treatment of 3rdrailphotography.com by: DNA Repair publishes full-length research articles, brief reports on research, and reviews.

The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day.

Comprehensive and cutting-edge, DNA Repair in Cancer Therapy surveys-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either.

The role of germ line defects in DNA repair genes in familial cancer are also indicated. The large role of DNA damage and consequent epigenetic DNA repair defects leading to sporadic cancer are emphasized. The roles of germ line mutation and directly induced somatic mutation in sporadic cancer are indicated as Cited by: In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Blocking DNA Repair in Advanced BRCA-Mutated Cancer was originally published by the National Cancer Institute.”.

The Trouble with DNA Repair. One in three women with ovarian cancer has tumors that are unable to repair a certain kind of DNA damage. Harmful mutations in the BRCA1 and BRCA2 genes, for example, lead to faulty DNA repair.

Tumors that lack this crucial DNA repair ability are called homologous recombination deficient, or HRD. PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair.

In addition, a description of discovery of the PARP family, and other DNABrand: Humana Press. In book: New Research Directions in DNA repair, Chapter: DNA Repair and Resistance to Cancer Therapy, Publisher: InTech, Editors: Clark Chen, pp Cite this publication.

This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells.

In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor 3rdrailphotography.com: Lesley A Mathews.

Cancer can be treated by surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy (including immunotherapy such as monoclonal antibody therapy) and synthetic 3rdrailphotography.com choice of therapy depends upon the location and grade of the tumor and the stage of the disease, as well as the general state of the patient (performance status).

J Cancer Sci Ther ISSN JCST, an open access journal DNA Damage and Repair in Cancer Therapy or apyrimidinic site is recognized by an endonuclease that produces a nick at site 5’ DNA. DNA Repair Importance. DNA in the living cell is subject to many chemical alterations (a fact often forgotten in the excitement of being able to do DNA sequencing on dried and/or frozen specimens []).If the genetic information encoded in the DNA is to remain uncorrupted, any chemical changes must be.

DNA damaging such as cisplatin, mitomycin C, and radiation are commonly used in the treatment of muscle-invasive or metastatic bladder cancer, and several recent studies have linked specific DNA repair pathway defects with sensitivity to DNA damaging-based therapy.

In addition, tumor DNA repair defects have important implications for use of Cited by: 9. With other case, little folks like to read book DNA Repair in Cancer Therapy: Molecular Targets and Clinical Applications. You can choose the best book if you want reading a book.

Given that we know about how is important a new book DNA Repair in Cancer Therapy: Molecular Targets and. Oct 29,  · Methods to identify HRD cancers and broaden the applicability of DNA repair inhibitors are being evaluated in the clinic. Nonhomologous recombinant DNA repair pathways, such as mismatch repair and nonhomologous end-joining, represent important targets for novel therapeutic strategies in gynecologic 3rdrailphotography.com by: 4.

Resistance of melanoma to radiotherapy and chemotherapy is commonly attributed to specific regulation of DNA Repair. Recent advances in our understanding of the molecular factors driving malignant transformation have led to the classification of melanoma based on specific gene mutations, and the development of targeted therapies.

DNA Repair and Resistance to Cancer Therapy António S. Rodrigues, Bruno Costa Gomes, Célia Martins, Marta Gromicho, Nuno G. Oliveira, Patrícia S. Guerreiro and José Rueff One of the most well-known examples of a defect in DNA repair leading to cancer is the.

Cancer can be treated by surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy (including immunotherapy such as monoclonal antibody therapy) and synthetic 3rdrailphotography.com choice of therapy depends upon the location and grade of the tumor and the stage of the disease, as well as the general state of the patient (performance status).Specialty: oncology.

An exciting finding was the identification of mrt-2, a gene responsible for germline immortality (Ahmed and Hodgkin, ). mrt-2 mutants exhibit progressive telomere shortening and accumulate end-to-end chromosome fusions. In addition, mrt-2 mutants are defective in DNA damage-induced mitotic arrest and apoptosis in the germline (Gartner et al., ).

DNA Repair and Cancer: From Bench to Clinic - CRC Press Book DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species.

The second section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets and therapeutic aspects.

Dec 15,  · The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer 3rdrailphotography.com by: Pathways that Can Repair Brca1 Cancer Gene Mutation Clarified in Mice.

Pathways that Can Repair Brca1 Cancer Gene Mutation Clarified in Mice. "Promoting HR by using drugs that inhibit toxic pathways for DNA repair could greatly reduce the development of breast and ovarian cancer in women with BRCA1 mutations," said Nussenzweig.

Jun 21,  · DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer 3rdrailphotography.com: Mark Kelley, Melissa Fishel.

The Impact of DNA Repair Pathways in Cancer Biology and Therapy. by Anatoly Nikolaev and Eddy S. Yang * Department of Radiation Oncology, UAB Comprehensive Cancer Center, Birmingham, ALUSA Yang, E.S. The Impact of DNA Repair Pathways in Cancer Biology and Therapy. Cancers9, Show more citation formats.

Note that from the Cited by: 8. The agreements will enable the continued commercial development of Professor Jackson's research into DNA repair. KuDOS develops potent and highly selective small molecule therapies that block DNA repair in cancer cells, making tumours more vulnerable to the fatal DNA-disrupting effects of both radiotherapy and chemotherapy.

Jan 22,  · The newest anti-aging ingredients are also key players in the fight against skin cancer. April Long explores DNA repair enzymes, which might be.

If the rate of DNA damage exceeds the capacity of the cell to repair it, the accumulation of errors can overwhelm the cell and result in cancer. A few important DNA repair genes: BRCA1 and BRCA2 CISN Summary: Oncogenes, Tumor-Suppressor Genes and DNA Repair Genes.It is therefore worth pursuing new strategies of cancer therapy that target DNA repair.

Numerous studies also support the notion that diet could influence cancer development, progression, metastasis and mortality. Furthermore, these studies suggest that susceptibility to various cancers is due to environmental factors, that is, diet, rather Cited by: DNA repair pathways and the effect of radiotherapy in breast cancer Karin Söderlund Leifler Linköping University Department of Clinical and Experimental Medicine Division of Surgery and Clinical Oncology SE Linköping, Sweden Linköping

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